Services
POLYMORPHISM SCREENING
Complete scientific support to discover and characterize the most relevant polymorphs of a drug
SALT SELECTION
Systematic salt screening studies to discover and select the salt derivative of an API
CO-CRYSTAL SCREENING
Co-crystals are an alternative to salts when these do not have the appropriate solid state properties or cannot be formed
Crystallization
Chiral Resolution
Salt selection studies
Discovery, characterization and scale-up of crystalline salts
Crysforma offers systematic salt screening studies to discover and select the salt derivative of an API with optimal solid state properties.
Preparation of a salt is the classical strategy to optimize the solid state properties of an active pharmaceutical ingredient. Salt derivatives can improve crystallinity, solubility and stability of a pharmaceutical compound, and are often chosen instead of the free acid or base.
Crysforma has developed its own salt screening methodology based in the use of selected crystallization procedures in an optimized group of crystallization solvents. The methodology allows performing 1000 crystallization experiments from 10 g of starting API under controlled conditions.
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Type of studies:
- Salt screening of pharmaceutical ingredients with selected counterions
- Characterization of crystalline salts
- Development of reliable preparation procedures
- Scale-up of the selected salt
